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Both this subgroup and the 18 subjects with a normal Schilling test had low serum cobalamin concentrations at baseline, which increased significantly to normal range within 4 weeks of treatment [276 69 vs 96 15 pmol l 1 (CI 95% 130.5, 231.3)

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Its ability to influence the expression of over 4,000 genes many involved in tissue repair and regeneration has made it a uniquely interesting compound